Journal article
Synthesis of truncated analogues of the iNKT cell agonist, α-galactosyl ceramide (KRN7000), and their biological evaluation.
- Abstract:
-
Stimulation of iNKT cells by α-galactosyl ceramide (α-GalCer), also known as KRN7000, and its truncated analogue OCH induces both Th1- and Th2-cytokines, with OCH inducing a Th2-cytokine bias. Skewing of the iNKT cells' response towards either a Th1- or Th2-cytokine profile offers potential therapeutic benefits. The length of both the acyl and the sphingosine chains in α-galactosyl ceramides is known to influence the cytokine release profile. We have synthesized analogues of α-GalCer with tru...
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- Publication status:
- Published
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- Publisher copy:
- 10.1016/j.bmc.2010.11.032
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Bibliographic Details
- Journal:
- Bioorganic and medicinal chemistry
- Volume:
- 19
- Issue:
- 1
- Pages:
- 221-228
- Publication date:
- 2011-01-01
- DOI:
- EISSN:
-
1464-3391
- ISSN:
-
0968-0896
- Source identifiers:
-
107185
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:107185
- UUID:
-
uuid:c3cfe35d-d305-4839-8870-7f8db4132651
- Local pid:
- pubs:107185
- Deposit date:
- 2012-12-19
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- Copyright date:
- 2011
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