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Synthesis of truncated analogues of the iNKT cell agonist, α-galactosyl ceramide (KRN7000), and their biological evaluation.

Abstract:

Stimulation of iNKT cells by α-galactosyl ceramide (α-GalCer), also known as KRN7000, and its truncated analogue OCH induces both Th1- and Th2-cytokines, with OCH inducing a Th2-cytokine bias. Skewing of the iNKT cells' response towards either a Th1- or Th2-cytokine profile offers potential therapeutic benefits. The length of both the acyl and the sphingosine chains in α-galactosyl ceramides is known to influence the cytokine release profile. We have synthesized analogues of α-GalCer with tru...

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Publication status:
Published

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Publisher copy:
10.1016/j.bmc.2010.11.032

Authors


Veerapen, N More by this author
Reddington, F More by this author
Cerundolo, V More by this author
Journal:
Bioorganic and medicinal chemistry
Volume:
19
Issue:
1
Pages:
221-228
Publication date:
2011-01-05
DOI:
EISSN:
1464-3391
ISSN:
0968-0896
URN:
uuid:c3cfe35d-d305-4839-8870-7f8db4132651
Source identifiers:
107185
Local pid:
pubs:107185

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