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The robustness of proofreading to crowding-induced pseudo-processivity in the MAPK pathway

Abstract:

Double phosphorylation of protein kinases is a common feature of signalling cascades. This motif may reduce cross-talk between signalling pathways, as the second phosphorylation site allows for proofreading, especially when phosphorylation is distributive rather than processive. Recent studies suggest that phosphorylation can be `pseudo-processive' in the crowded cellular environment, as rebinding after the first phosphorylation is enhanced by slow diffusion. Here, we use a simple model with ...

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Ouldridge, TE More by this author
Wolde, PRT More by this author
Publication date:
2014-07-06
URN:
uuid:c397681d-8a81-4c8e-849d-0fd13fe684bf
Source identifiers:
476121
Local pid:
pubs:476121

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