Abstract:

Double phosphorylation of protein kinases is a common feature of signalling cascades. This motif may reduce cross-talk between signalling pathways, as the second phosphorylation site allows for proofreading, especially when phosphorylation is distributive rather than processive. Recent studies suggest that phosphorylation can be `pseudo-processive' in the crowded cellular environment, as rebinding after the first phosphorylation is enhanced by slow diffusion. Here, we use a simple model with ...

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