Journal article
The robustness of proofreading to crowding-induced pseudo-processivity in the MAPK pathway
- Abstract:
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Double phosphorylation of protein kinases is a common feature of signalling cascades. This motif may reduce cross-talk between signalling pathways, as the second phosphorylation site allows for proofreading, especially when phosphorylation is distributive rather than processive. Recent studies suggest that phosphorylation can be `pseudo-processive' in the crowded cellular environment, as rebinding after the first phosphorylation is enhanced by slow diffusion. Here, we use a simple model with ...
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Bibliographic Details
- Publication date:
- 2014-07-06
- Source identifiers:
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476121
Item Description
- Keywords:
- Pubs id:
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pubs:476121
- UUID:
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uuid:c397681d-8a81-4c8e-849d-0fd13fe684bf
- Local pid:
- pubs:476121
- Deposit date:
- 2014-07-19
Terms of use
- Copyright date:
- 2014
- Notes:
- To appear in Biohys. J
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