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The role of macrophages in the generation of T-helper cells. I. The requirement for macrophages in helper cell induction and characteristics of the macrophage-T cell interaction.

Abstract:

The role of macrophages in the induction of helper cells in vitro was investigated. Using either soluble or particulate antigens, macrophages were found to be essential. This was true regardless of the anatomical source of the T cells (spleen, lymph node or the cortisone resistant pool of the thymus), or of the method of macrophage depletion, (adherence to polystyrene or nylon wool, or by the use of carbonyl iron). There were some differences, however, depending on the physical nature of the ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Journal:
Cellular immunology
Volume:
19
Issue:
2
Pages:
356-367
Publication date:
1975-10-05
DOI:
EISSN:
1090-2163
ISSN:
0008-8749
URN:
uuid:c387b645-1fc5-4e17-bc83-691269316cef
Source identifiers:
481956
Local pid:
pubs:481956

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