Journal article

Toolbox study for application of hydrogen peroxide as a versatile, safe and industrially-relevant green oxidant in continuous flow mode

Abstract:: Hydrogen peroxide embodies an ideal oxidant in terms of atom-economy, availability and green metrics. However, its use has been limited because of risks associated with disproportionation and the exothermic potential of oxidizing reaction mixtures. This study aims to showcase the versatility of hydrogen peroxide in a range of oxidations, while ensuring that such processes operate practically and with a defined and minimized risk. To offset the hazards of using peroxides, continuous-flow equipment was utilized to limit the volume of unquenched peroxides and to maintain process control. A methodological approach was established relying on kinetic and calorimetric understanding. Finally, scalability was highlighted in an organocatalysed heterocyclic N-oxidation using a cascade of stirred tank reactors with nitrogen flushing.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Martin, B., Sedelmeier, J., Bouisseau, A., Fernandez-Rodriguez, P., Haber, J., Kleinbeck, F., Kamptmann, S., Susanne, F., Hoehn, P., Lanz, M., Pellegatti, L., Venturoni, F., Robertson, J., Willis, M., & Schenkel, B. (2016). Toolbox study for application of hydrogen peroxide as a versatile, safe and industrially-relevant green oxidant in continuous flow mode. Green Chemistry, 19(6), 1439–1448.

MLA Style

Martin, B, et al. “Toolbox Study for Application of Hydrogen Peroxide as a Versatile, Safe and Industrially-Relevant Green Oxidant in Continuous Flow Mode.” Green Chemistry, vol. 19, no. 6, 2016, pp. 1439–48.

Chicago Style

Martin, B, J Sedelmeier, A Bouisseau, et al. 2016. “Toolbox Study for Application of Hydrogen Peroxide as a Versatile, Safe and Industrially-Relevant Green Oxidant in Continuous Flow Mode.” Green Chemistry 19 (6): 1439–48.
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Publisher copy:: 10.1039/C6GC02899C

Authors

+ Martin, B More by this author

Role:: Author

+ Sedelmeier, J More by this author

Role:: Author

+ Bouisseau, A More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Sub department:: Organic Chemistry
Role:: Author

+ Fernandez-Rodriguez, P More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Sub department:: Organic Chemistry
Role:: Author

+ Haber, J More by this author

Role:: Author

More authors...

+ European Union More from this funder

Grant:: People Programme (Marie Curie Actions) (FP7/2007–2013) under REA grant agreement no 316955

Publisher:: Royal Society of Chemistry
Journal:: Green Chemistry More from this journal
Volume:: 19
Issue:: 6
Pages:: 1439-1448
Publication date:: 2016-11-23
Acceptance date:: 2016-11-18
DOI:: 10.1039/C6GC02899C
EISSN:: 1463-9270
ISSN:: 1463-9262

Keywords:: Journal Article
Pubs id:: pubs:696540
UUID:: uuid:c37cf747-a2c4-4cfc-b7f7-10f41a7f9cde
Local pid:: pubs:696540
Source identifiers:: 696540
Deposit date:: 2017-06-07
ARK identifier:: ark:/29072/ora_c37cf747a2c44cfcb7f710f41a7f9cde

Terms of use

Copyright holder:: Martin et al
Copyright date:: 2016

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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