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A model for hepatic fibrosis: The competing effects of cell loss and iron on shortened Modified Look-Locker inversion recovery T1 (shMOLLI-T1) in the liver

Abstract:

Purpose: Liver T1 values have shown sensitivity to inflammation and fibrosis, but are also affected by hepatic iron content. Modified Look-Locker inversion recovery (MOLLI) T1 measurements are biased by the lower T2 associated with high iron. The purpose of this work is to propose a simple multi-compartment model of the liver and use Bloch-McConnell simulations to demonstrate the effects of iron and fibrosis on shortened-MOLLI (shMOLLI) T1 measurements.
Methods: A tissue model was genera...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1002/jmri.25392

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, RDM Cardiovascular Medicine
Role:
Author
NIHR Oxford Biomedical Research Centre More from this funder
UK Department of Health More from this funder
Publisher:
Wiley Publisher's website
Journal:
Journal of Magnetic Resonance Imaging Journal website
Volume:
45
Issue:
2
Pages:
450-462
Publication date:
2016-07-23
Acceptance date:
2016-07-05
DOI:
EISSN:
1522-2586
ISSN:
1053-1807
URN:
uuid:c37bae45-7717-43fb-ad73-21ae65f6c614
Source identifiers:
633912
Local pid:
pubs:633912
Paper number:
2

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