- Abstract:
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Purpose: Liver T1 values have shown sensitivity to inflammation and fibrosis, but are also affected by hepatic iron content. Modified Look-Locker inversion recovery (MOLLI) T1 measurements are biased by the lower T2 associated with high iron. The purpose of this work is to propose a simple multi-compartment model of the liver and use Bloch-McConnell simulations to demonstrate the effects of iron and fibrosis on shortened-MOLLI (shMOLLI) T1 measurements.
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Methods: A tissue model was genera... - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted manuscript
- Files:
-
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(pdf, 395.0KB)
-
- Publisher copy:
- 10.1002/jmri.25392
-
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- Publisher:
- Wiley Publisher's website
- Journal:
- Journal of Magnetic Resonance Imaging Journal website
- Volume:
- 45
- Issue:
- 2
- Pages:
- 450-462
- Publication date:
- 2016-07-23
- Acceptance date:
- 2016-07-05
- DOI:
- EISSN:
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1522-2586
- ISSN:
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1053-1807
- URN:
-
uuid:c37bae45-7717-43fb-ad73-21ae65f6c614
- Source identifiers:
-
633912
- Local pid:
- pubs:633912
- Paper number:
- 2
- Keywords:
- Copyright holder:
- International Society for Magnetic Resonance in Medicine
- Copyright date:
- 2016
- Notes:
- © International Society for Magnetic Resonance in Medicine. Published by Wiley.
Journal article
A model for hepatic fibrosis: The competing effects of cell loss and iron on shortened Modified Look-Locker inversion recovery T1 (shMOLLI-T1) in the liver
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NIHR Oxford Biomedical Research Centre
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