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Conventional and genetic evidence on the association between adiposity and chronic kidney disease

Abstract:

Background: The size of any causal contribution of central and general adiposity to chronic kidney disease (CKD) risk and the underlying mechanism of mediation are unknown.

Methods: 281,228 UK Biobank participants were included in estimates of the relevance of waist-to-hip ratio and body-mass index (BMI) to CKD prevalence. Conventional approaches used logistic regression. Genetic analyses employed Mendelian Randomisation and data from 394 waist-to-...

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Publication status:
Accepted
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Role:
Author
ORCID:
0000-0002-1632-8989
More by this author
Institution:
University of Oxford
Division:
MSD
Subgroup:
Clinical Trial Service Unit
Role:
Author
ORCID:
0000-0003-1172-8243
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Role:
Author
ORCID:
0000-0002-1179-0023
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Role:
Author
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Publisher:
American Society of Nephrology Publisher's website
Journal:
Journal of the American Society of Nephrology Journal website
Publication date:
2020-10-30
Acceptance date:
2020-09-09
DOI:
EISSN:
1533-3450
ISSN:
1046-6673
Pubs id:
1132498
Local pid:
pubs:1132498
Language:
English
Keywords:

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