Journal article : Review
IL-23 past, present, and future: a roadmap to advancing IL-23 science and therapy
- Abstract:
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Interleukin (IL)-23, an IL-12 cytokine family member, is a hierarchically dominant regulatory cytokine in a cluster of immune-mediated inflammatory diseases (IMIDs), including psoriasis, psoriatic arthritis, and inflammatory bowel disease. We review IL-23 biology, IL-23 signaling in IMIDs, and the effect of IL-23 inhibition in treating these diseases. We propose studies to advance IL-23 biology and unravel differences in response to anti–IL-23 therapy. Experimental evidence generated from the...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.6MB, Terms of use)
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- Publisher copy:
- 10.3389/fimmu.2024.1331217
Authors
Bibliographic Details
- Publisher:
- Frontiers Media
- Journal:
- Frontiers in Immunology More from this journal
- Volume:
- 15
- Article number:
- 1331217
- Publication date:
- 2024-04-15
- Acceptance date:
- 2024-03-21
- DOI:
- EISSN:
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1664-3224
Item Description
- Language:
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English
- Keywords:
- Subtype:
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Review
- Source identifiers:
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1929203
- Deposit date:
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2024-07-20
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