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Journal article

Mosaic loss of chromosome Y in blood is associated with Alzheimer disease

Abstract:

Men have a shorter life expectancy compared with women but the underlying factor(s) are not clear. Late-onset, sporadic Alzheimer disease (AD) is a common and lethal neurodegenerative disorder and many germline inherited variants have been found to influence the risk of developing AD. Our previous results show that a fundamentally different genetic variant, i.e., lifetime-acquired loss of chromosome Y (LOY) in blood cells, is associated with all-cause mortality and an increased risk of non-he...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.ajhg.2016.05.014

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Funding agency for:
Dumanski, JP
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Funding agency for:
Dumanski, JP
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Funding agency for:
Dumanski, JP
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Publisher:
Elsevier (Cell Press) Publisher's website
Journal:
American journal of human genetics Journal website
Volume:
98
Issue:
6
Pages:
1208-1219
Publication date:
2016-06-02
DOI:
EISSN:
1537-6605
ISSN:
0002-9297
URN:
uuid:c3643c04-5c0f-4ab2-bb0c-dc576e1b8d60
Source identifiers:
624923
Local pid:
pubs:624923

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