Journal article icon

Journal article

Conformational dynamics of the molecular chaperone Hsp90 in complexes with a co-chaperone and anticancer drugs.

Abstract:

The molecular chaperone Hsp90 is essential for the correct folding, maturation and activation of a diverse array of client proteins, including several key constituents of oncogenic processes. Hsp90 has become a focus of cancer research, since it represents a target for direct prophylaxis against multistep malignancy. Hydrogen-exchange mass spectrometry was used to study the structural and conformational changes undergone by full-length human Hsp90beta in solution upon binding of the kinase-sp...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1016/j.jmb.2007.04.059

Authors


Phillips, JJ More by this author
McLaughlin, S More by this author
Expand authors...
Journal:
Journal of molecular biology
Volume:
372
Issue:
5
Pages:
1189-1203
Publication date:
2007-10-05
DOI:
EISSN:
1089-8638
ISSN:
0022-2836
URN:
uuid:c3619ba0-4bb6-4549-9348-b0fffa75412a
Source identifiers:
59304
Local pid:
pubs:59304

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP