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PIM kinases are progression markers and emerging therapeutic targets in diffuse large B-cell lymphoma

Abstract:

Background: PIM serine/threonine kinases are often highly expressed in haematological malignancies. We have shown that PIM inhibitors reduced the survival and migration of leukaemic cells. Here, we investigated PIM kinases in diffuse large B-cell lymphoma (DLBCL) biopsy samples and DLBCL cell lines.Methods:Immunohistochemical staining for PIM kinases and CXCR4 was performed on tissue microarrays from a cohort of 101 DLBCL cases, and the effects of PIM inhibitors on the survival and migration ...

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Publisher copy:
10.1038/bjc.2012.272

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Genomics Consortium
Role:
Author
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Journal:
British Journal of Cancer
Volume:
107
Issue:
3
Pages:
491-500
Publication date:
2012-07-24
DOI:
EISSN:
1532-1827
ISSN:
0007-0920
URN:
uuid:c3400496-b2e4-470b-8e3f-2dc7b48c18bd
Source identifiers:
348837
Local pid:
pubs:348837

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