Temporal organization of the cell cycle.

Journal article

The coordination of growth, DNA replication and division in proliferating cells can be adequately explained by a 'clock + checkpoint' model. The clock is an underlying cyclical sequence of states; the checkpoints ensure that the cycle proceeds without mistakes. From the molecular complexities of the control system in modern eukaryotes, we isolate a simple network of positive and negative feedbacks that embodies a 'clock + checkpoints'. The model accounts for the fundamental physiological properties of mitotic cell divisions, evokes a new view of the meiotic program, and suggests how the control system may have evolved in the first place.

Authors: Tyson, J; Novak, B

• Publication status: Published
• Journal: Current biology : CB
• Volume: 18
• Issue: 17
• Pages: R759-R768
• Publication date: 2008-09-01
• DOI: 10.1016/j.cub.2008.07.001
• EISSN: 1879-0445
• ISSN: 0960-9822
• Language: English
• Keywords: Cell Cycle; Models, Biological; Cyclin-Dependent Kinases; Eukaryotic Cells