Pre-metastatic niches: organ-specific homes for metastases

Journal article

It is well established that organs of future metastasis are not passive receivers of circulating tumour cells, but are instead selectively and actively modified by the primary tumour before metastatic spread has even occurred. Sowing the 'seeds' of metastasis requires the action of tumour-secreted factors and tumour-shed extracellular vesicles that enable the 'soil' at distant metastatic sites to encourage the outgrowth of incoming cancer cells. In this Review, we summarize the main processes and new mechanisms involved in the formation of the pre-metastatic niche.

Authors: Peinado, H; Zhang, H; Matei, I; Costa-Silva, B; Hoshino, A

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Nature Research
• Journal: Nature Reviews Cancer
• Volume: 17
• Pages: 302–317
• Publication date: 2017-03-17
• Acceptance date: 2017-01-01
• DOI: 10.1038/nrc.2017.6
• EISSN: 1474-1768
• ISSN: 1474-175X
• Pmid: 28303905
• Language: English
• Keywords: cancer microenvironment; tumour biomarkers; cancer models; tumour immunology; metastasis