Journal article
What are the long-term symptoms and complications of COVID-19: a protocol for a living systematic review
- Abstract:
- Although the majority of people with Covid-19 will experience mild to moderate symptoms and will recover fully, there is now increasing evidence that a significant proportion will experience persistent symptoms for months after the acute phase of the illness. These symptoms include, among others, fatigue, problems breathing, lack of smell and taste, headaches, and depression and anxiety. It is also clear the virus has lasting fluctuating multiorgan sequelae, including affecting not only the respiratory system but also the heart, liver, and nervous system. We present a protocol for a living systematic review that aims to synthesize the evidence on the prevalence and characteristics of post-acute COVID-19. The living systematic review will be updated regularly, approximately every 6 months, as new evidence emerges. We will include studies that follow up at least 100 people with Covid-19 at 12 or more weeks post Covid-19 onset, with no restrictions regarding country, setting, or language. We will use descriptive statistics and, for outcomes reported in two or more studies, we will use meta-analyses to estimate prevalence with 95% confidence intervals (CIs) using the exact method. Heterogeneity between estimates will be assessed using the I2 statistic. Our findings will also be presented as infographics to facilitate transcription to lay audiences. Ultimately, we aim to support the work of policy makers, practitioners, and patients when planning rehabilitation for those recovering from Covid-19. The protocol has been registered with PROSPERO ( CRD42020211131, 25/09/2020).
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 909.0KB, Terms of use)
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- Publisher copy:
- 10.12688/f1000research.27284.2
Authors
- Publisher:
- F1000Research
- Journal:
- F1000Research More from this journal
- Volume:
- 9
- Article number:
- 1455
- Place of publication:
- England
- Publication date:
- 2020-12-14
- Acceptance date:
- 2021-08-27
- DOI:
- EISSN:
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2046-1402
- ISSN:
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2046-1402
- Pmid:
-
34621523
- Language:
-
English
- Keywords:
- Pubs id:
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1202562
- Local pid:
-
pubs:1202562
- Deposit date:
-
2024-04-18
Terms of use
- Copyright holder:
- Michelen et al.
- Copyright date:
- 2020
- Rights statement:
- © 2021 Michelen M et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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