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Journal article

How best to identify chromosomal interactions: a comparison of approaches.

Abstract:

Chromosome conformation capture (3C) methods are central to understanding the link between nuclear structure and function, and the physical interactions between distal regulatory elements and promoters. However, no one method is appropriate to address all biological questions, as each variant differs markedly in resolution, reproducibility, throughput and biases. A thorough appreciation of the strengths and weaknesses of each technique is critical when choosing the correct method for a specif...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/nmeth.4146

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Clinical Laboratory Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Clinical Laboratory Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Clinical Laboratory Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Clinical Laboratory Sciences
Role:
Author
More from this funder
Funding agency for:
Davies, J
Grant:
098931/Z/12/Z
More from this funder
Funding agency for:
Oudelaar, M
Grant:
105281/Z/14/Z
More from this funder
Funding agency for:
Higgs, D
Grant:
106130/Z/14/Z
More from this funder
Funding agency for:
Hughes, J
Grant:
106130/Z/14/Z
Publisher:
Springer Nature Publisher's website
Journal:
Nat Methods Journal website
Volume:
14
Issue:
2
Pages:
125-134
Publication date:
2017-01-31
Acceptance date:
2016-12-20
DOI:
EISSN:
1548-7105
ISSN:
1548-7091
Source identifiers:
679684
Language:
English
Subjects:
Pubs id:
pubs:679684
UUID:
uuid:c233180b-e4a2-4288-b022-95549eb90d84
Local pid:
pubs:679684
Deposit date:
2017-06-22

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