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How best to identify chromosomal interactions: a comparison of approaches.

Abstract:

Chromosome conformation capture (3C) methods are central to understanding the link between nuclear structure and function, and the physical interactions between distal regulatory elements and promoters. However, no one method is appropriate to address all biological questions, as each variant differs markedly in resolution, reproducibility, throughput and biases. A thorough appreciation of the strengths and weaknesses of each technique is critical when choosing the correct method for a specif...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1038/nmeth.4146

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Department:
Oxford, MSD, RDM, RDM Clinical Laboratory Sciences
Role:
Author
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Department:
Oxford, MSD, RDM, RDM Clinical Laboratory Sciences
Role:
Author
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Department:
Oxford, MSD, RDM, RDM Clinical Laboratory Sciences
Role:
Author
More by this author
Department:
Oxford, MSD, RDM, RDM Clinical Laboratory Sciences
Role:
Author
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Funding agency for:
Davies, JO
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Funding agency for:
Oudelaar, AM
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Funding agency for:
Higgs, DR
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Funding agency for:
Hughes, JR
Publisher:
Springer Nature Publisher's website
Journal:
Nat Methods Journal website
Volume:
14
Issue:
2
Pages:
125-134
Publication date:
2017-01-31
Acceptance date:
2016-12-20
DOI:
EISSN:
1548-7105
ISSN:
1548-7091
Pubs id:
pubs:679684
URN:
uri:c233180b-e4a2-4288-b022-95549eb90d84
UUID:
uuid:c233180b-e4a2-4288-b022-95549eb90d84
Local pid:
pubs:679684

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