Journal article

A mathematical model of Doxorubicin treatment efficacy on non-Hodgkin’s lymphoma: Investigation of current protocol through theoretical modelling results

Abstract:: Doxorubicin treatment outcomes for non-Hodgkin’s lymphomas (NHL) are mathematically modelled and computationally analyzed. The NHL model includes a tumor structure incorporating mature and immature vessels, vascular structural adaptation and NHL cell-cycle kinetics in addition to Doxorubicin pharmacokinetics (PK) and pharmacodynamics (PD). Simulations provide qualitative estimations of the effect of Doxorubicin on high-grade (HG), intermediate-grade (IG) and low-grade (LG) NHL. Simulation results imply that if the interval between successive drug applications is prolonged beyond a certain point, treatment will be inefficient due to effects caused by heterogeneous blood flow in the system.

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APA Style

Ribba, B., Marron, K., Agur, Z., Alarcon, T., & Maini, P. (2005). A mathematical model of Doxorubicin treatment efficacy on non-Hodgkin’s lymphoma: Investigation of current protocol through theoretical modelling results.

MLA Style

Ribba, B, et al. A Mathematical Model of Doxorubicin Treatment Efficacy on Non-Hodgkin’s Lymphoma: Investigation of Current Protocol through Theoretical Modelling Results. 2005.

Chicago Style

Ribba, B, K Marron, Z Agur, T Alarcon, and P Maini. 2005. A Mathematical Model of Doxorubicin Treatment Efficacy on Non-Hodgkin’s Lymphoma: Investigation of Current Protocol through Theoretical Modelling Results.
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+ Ribba, B More by this author

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+ Marron, K More by this author

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+ Agur, Z More by this author

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+ Alarcon, T More by this author

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+ Maini, P More by this author

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Publication date:: 2005-01-01

UUID:: uuid:c1f3884e-4d16-4e79-8414-7411847cdf47
Local pid:: oai:eprints.maths.ox.ac.uk:352
Deposit date:: 2011-05-19
ARK identifier:: ark:/29072/ora_c1f3884e4d164e7984147411847cdf47

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Copyright date:: 2005

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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