Ion microscope imaging mass spectrometry using a Timepix3-based optical camera

Journal article

Ion microscopy allows for high-throughput mass spectrometry imaging. In order to resolve congested mass spectra, a high degree of timing precision is required from the microscope detector. In this paper we present an ion microscope mass spectrometer that uses a Timepix3 hybrid pixel readout with an optimal 1.56 ns resolution. A novel triggering technique is also employed to remove the need for an external time-to-digital converter (TDC) and allow the experiment to be performed using a low-cost and commercially available readout system. Results obtained from samples of rhodamine B demonstrate the application of multimass imaging sensors for microscope mass spectrometry imaging with high mass resolution.

Authors: Wood, D; Burleigh, RJ; Smith, N; Bortoletto, D; Brouard, M

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: American Chemical Society
• Journal: Journal of the American Society for Mass Spectrometry
• Volume: 33
• Issue: 12
• Pages: 2328-2332
• Publication date: 2022-11-16
• Acceptance date: 2022-11-02
• DOI: 10.1021/jasms.2c00223
• EISSN: 1879-1123
• ISSN: 1044-0305
• Language: English
• Keywords: FFR