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Polygenic Scores and Networks of Psychopathology Symptoms

Abstract:

Importance Studies on polygenic risk for psychiatric traits commonly use a disorder-level approach to phenotyping, implicitly considering disorders as homogeneous constructs; however, symptom heterogeneity is ubiquitous, with many possible combinations of symptoms falling under the same disorder umbrella. Focusing on individual symptoms may shed light on the role of polygenic risk in psychopathology.Objective To determine whether polygenic scores are associated with all symptoms of psychiatri...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1001/jamapsychiatry.2024.1403

Authors

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Institution:
University of Oxford
Role:
Author
ORCID:
0000-0002-0117-7241
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Role:
Author
ORCID:
0000-0003-4048-4292
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Role:
Author
ORCID:
0000-0001-6458-0700
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Role:
Author
ORCID:
0000-0003-4884-8118
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Role:
Author
ORCID:
0000-0001-7469-594X


Publisher:
American Medical Association
Journal:
JAMA Psychiatry More from this journal
Volume:
81
Issue:
9
Pages:
902-902
Publication date:
2024-06-12
DOI:
EISSN:
2168-6238
ISSN:
2168-622X


Language:
English
Keywords:
Pubs id:
2432659
Local pid:
pubs:2432659
Source identifiers:
W4399569141
Deposit date:
2026-06-12
ARK identifier:
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