Journal article
Mechanistic basis for potent neutralization of Sin Nombre hantavirus by a human monoclonal antibody
- Abstract:
- ultrastructure arrangement indicates that SNV-42 targets the membrane-distal region of the virus envelope. Comparison of the SNV-42 paratope encoding variable genes with inferred germline gene segments reveals high sequence conservation, suggesting that germline-encoded antibodies inhibit SNV. Furthermore, mechanistic assays reveal that SNV-42 interferes with both receptor recognition and fusion during host-cell entry. This work provides a molecular-level blueprint for understanding the human neutralizing antibody response to hantavirus infection.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 5.5MB, Terms of use)
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- Publisher copy:
- 10.1038/s41564-023-01413-y
Authors
+ Merck KGaA
More from this funder
- Funder identifier:
- 10.13039/100009945
- Grant:
- 2019 Future Insight Prize
+ Foundation for the National Institutes of Health
More from this funder
- Funder identifier:
- 10.13039/100000009
- Grant:
- 5T32GM008320-30
+ RCUK | Medical Research Council
More from this funder
- Funder identifier:
- 10.13039/501100000265
- Grant:
- MR/V031635/1
- Publisher:
- Nature Research
- Journal:
- Nature Microbiology More from this journal
- Volume:
- 8
- Issue:
- 7
- Pages:
- 1293-1303
- Publication date:
- 2023-06-15
- DOI:
- EISSN:
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2058-5276
- ISSN:
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2058-5276
- Language:
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English
- Keywords:
- Pubs id:
-
1468185
- Local pid:
-
pubs:1468185
- Source identifiers:
-
W4380870595
- Deposit date:
-
2026-05-08
- ARK identifier:
This ORA record was generated from metadata provided by an external service. It has not been edited by the ORA Team.
Terms of use
- Copyright date:
- 2023
- Licence:
- CC Attribution (CC BY)
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