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Galectin-9 is rapidly released during acute HIV-1 infection and remains sustained at high levels despite viral suppression even in elite controllers.

Abstract:

Galectin-9 (Gal-9) is a β-galactosidase-binding lectin that promotes apoptosis, tissue inflammation, and T cell immune exhaustion, and alters HIV infection in part through engagement with the T cell immunoglobulin mucin domain-3 (Tim-3) receptor and protein disulfide isomerases (PDI). Gal-9 was initially thought to be an eosinophil attractant, but is now known to mediate multiple complex signaling events that affect T cells in both an immunosuppressive and inflammatory manner. To understand t...

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Publication status:
Published

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Publisher copy:
10.1089/aid.2014.0004

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Role:
Author
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Publisher:
Mary Ann Liebert Inc.
Journal:
AIDS research and human retroviruses
Volume:
30
Issue:
7
Pages:
654-664
Publication date:
2014-07-05
DOI:
EISSN:
1931-8405
ISSN:
0889-2229
URN:
uuid:c1be35e1-e176-46b6-a5a5-36ae1886c5ba
Source identifiers:
463272
Local pid:
pubs:463272
Language:
English

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