Journal article
Typhoid conjugate vaccines: Advancing the research and public health agendas
- Abstract:
- The disease burden of typhoid fever remains high in endemic areas in Asia and Africa, especially in children. Recent clinical trials conducted by the Typhoid Vaccine Acceleration Consortium show typhoid conjugate vaccine (TCV) to be safe, immunogenic, and efficacious at preventing blood culture-confirmed typhoid fever in African and Asian children. Pakistan, Liberia, and Zimbabwe recently introduced TCV through campaigns and routine childhood immunizations, providing protection for this vulnerable population. It is essential to continue this momentum while simultaneously filling data gaps—including typhoid complications—to inform decision-making on TCV introduction. A multidisciplinary approach including surveillance, water, sanitation, and hygiene investments, and large-scale TCV introduction is needed to decrease the burden and mortality of typhoid fever.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 3.5MB, Terms of use)
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- Publisher copy:
- 10.1093/infdis/jiab449
Authors
+ National Institutes of Health
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- Funder identifier:
- http://dx.doi.org/10.13039/100000002
- Publisher:
- Oxford University Press
- Journal:
- Journal of Infectious Diseases More from this journal
- Volume:
- 224
- Issue:
- S7
- Pages:
- S781-S787
- Publication date:
- 2021-09-16
- Acceptance date:
- 2021-08-31
- DOI:
- EISSN:
-
1537-6613
- ISSN:
-
0022-1899
- Pmid:
-
34528085
- Language:
-
English
- Keywords:
- Pubs id:
-
1239368
- Local pid:
-
pubs:1239368
- Deposit date:
-
2022-02-20
- ARK identifier:
Terms of use
- Copyright holder:
- Birkhold et al.
- Copyright date:
- 2021
- Rights statement:
- © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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