High-resolution ion microscope imaging over wide mass ranges using electrodynamic post-extraction differential acceleration

Journal article

A time-dependent postextraction differential acceleration (PEDA) potential was used to temporally focus increasingly heavy ions in a stigmatic imaging mass spectrometer, allowing them to be imaged with high mass and spatial resolutions over a broad mass-to-charge (m/z) range. By applying a linearly rising potential to the ion extraction electrode, sequential m/z ratios were subjected to a changing electric field, allowing their foci to coincide at the detector. Using this approach, at least 75% of the maximum mass resolution was obtained over a 300–600 Da range when the ion microscope was focused around 450 Da, representing more than a 10-fold increase over the conventional single-field PEDA method.

Authors: Guo, A; Burleigh, RJ; Smith, N; Brouard, M; Burt, M

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: American Chemical Society
• Journal: Journal of The American Society for Mass Spectrometry
• Volume: 31
• Issue: 9
• Pages: 1903–1909
• Publication date: 2020-07-31
• Acceptance date: 2020-07-31
• DOI: 10.1021/jasms.0c00167
• EISSN: 1879-1123
• ISSN: 1044-0305
• Language: English
• Keywords: extraction; ions; electrodes; mass spectrometry; FFR; imaging