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Association of adult height and leg length with fasting plasma cortisol concentrations: evidence for an effect of normal variation in adrenocortical activity on growth.

Abstract:

We have evaluated the relationship between activity of the hypothalamic-pituitary-adrenal (HPA) axis and adult height in adults recruited from the UK Hertfordshire Cohort Study. In a sample of 1,354 individuals, we found that height fell by 0.67 cm (95% CI 0.34-1.0) per SD (114 nmol/l) increase in fasting plasma cortisol concentrations. The association was continuous across the range of cortisol concentrations and was independent of the levels of corticosteroid binding globulin. It was of sim...

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Publication status:
Published

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Publisher copy:
10.1002/ajhb.20803

Authors


Phillips, DI More by this author
Syddall, HE More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Hanson, MA More by this author
Journal:
American journal of human biology : the official journal of the Human Biology Council
Volume:
20
Issue:
6
Pages:
712-715
Publication date:
2008
DOI:
EISSN:
1520-6300
ISSN:
1042-0533
URN:
uuid:c14a1e89-c626-4f26-83f3-5a4c3738b0f6
Source identifiers:
125490
Local pid:
pubs:125490

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