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Contribution of nosocomial transmission to Klebsiella pneumoniae neonatal sepsis in Africa and South Asia: An observational study of infection clusters inferred from pathogen genomics and temporal data

Abstract:

Background: Klebsiella pneumoniae is the leading cause of sepsis among neonates in low- and middle-income countries (LMICs) in Africa and Asia, contributing substantially to the overall burden of antimicrobial-resistant infections and mortality among neonates globally. Pathogen sequencing has been used to investigate case clusters and confirm nosocomial transmission in a small number of neonatal units. Here we utilise pathogen sequence data to estimate the fraction of K. pneumoniae neonatal s...

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Publication status:
Published
Peer review status:
Peer reviewed

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Role:
Author
ORCID:
0000-0003-4503-9403
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Role:
Author
ORCID:
0000-0001-6744-0500
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Role:
Author
ORCID:
0000-0002-4586-1985
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Role:
Author
ORCID:
0000-0003-0464-1529
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Role:
Author
ORCID:
0000-0003-4413-3756


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Funder identifier:
https://ror.org/029chgv08
Grant:
217303/Z/19/Z
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Funder identifier:
https://ror.org/03hnrwx04
Grant:
12036
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Funder identifier:
https://ror.org/0456r8d26
Grant:
INV049364
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Funder identifier:
10.13039/100004319


Publisher:
Public Library of Science
Journal:
PLoS Medicine More from this journal
Volume:
23
Issue:
5
Pages:
e1005077
Article number:
e1005077
Publication date:
2026-05-13
Acceptance date:
2026-04-15
DOI:
EISSN:
1549-1676
ISSN:
1549-1277


Language:
English
Keywords:
Source identifiers:
4061028
Deposit date:
2026-05-19
ARK identifier:
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