- Abstract:
-
Small intestinal microparticle uptake via a paracellular route is relevant to oral drug delivery and environmental pollution. In vitro investigation uses latex microparticle passage across a confluent Caco-2 cell epithelium. This paper examines the influence of culture conditions on transepithelial resistance (TER); cell dimensions from confocal microscopy; and number of particles below the epithelium. Variables investigated include level of initial TER; multiple TER measurements; involvement...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/j.ijpharm.2009.11.027
-
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- Journal:
- International journal of pharmaceutics
- Volume:
- 387
- Issue:
- 1-2
- Pages:
- 7-18
- Publication date:
- 2010-03-05
- DOI:
- EISSN:
-
1873-3476
- ISSN:
-
0378-5173
- URN:
-
uuid:c0fdf7ac-86f9-475a-aaf9-3304f7b59302
- Source identifiers:
-
113643
- Local pid:
- pubs:113643
- Language:
- English
- Keywords:
- Copyright date:
- 2010
Journal article
Culture conditions and treatments affect Caco-2 characteristics and particle uptake.
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