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Journal article

Culture conditions and treatments affect Caco-2 characteristics and particle uptake.

Abstract:

Small intestinal microparticle uptake via a paracellular route is relevant to oral drug delivery and environmental pollution. In vitro investigation uses latex microparticle passage across a confluent Caco-2 cell epithelium. This paper examines the influence of culture conditions on transepithelial resistance (TER); cell dimensions from confocal microscopy; and number of particles below the epithelium. Variables investigated include level of initial TER; multiple TER measurements; involvement...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Journal:
International journal of pharmaceutics
Volume:
387
Issue:
1-2
Pages:
7-18
Publication date:
2010-03-05
DOI:
EISSN:
1873-3476
ISSN:
0378-5173
URN:
uuid:c0fdf7ac-86f9-475a-aaf9-3304f7b59302
Source identifiers:
113643
Local pid:
pubs:113643

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