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Journal article

Population parameters underlying an ongoing soft sweep in Southeast Asian malaria parasites

Abstract:

Multiple kelch13 alleles conferring artemisinin resistance (ART-R) are currently spreading through Southeast Asian malaria parasite populations, providing a unique opportunity to observe an ongoing soft selective sweep, investigate why resistance alleles have evolved multiple times and determine fundamental population genetic parameters for Plasmodium. We sequenced kelch13 (n = 1,876), genotyped 75 flanking SNPs, and measured clearance rate (n = 3,552) in parasite infections from Western Thai...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1093/molbev/msw228

Authors


Anderson, TJC More by this author
McDew-White, M More by this author
Cheeseman, IH More by this author
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Bill and Melinda Gates Foundation More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
Molecular Biology and Evolution Journal website
Volume:
34
Issue:
1
Pages:
131–144
Publication date:
2016-10-20
Acceptance date:
2016-10-10
DOI:
EISSN:
1537-1719
ISSN:
0737-4038
Pubs id:
pubs:667681
URN:
uri:c0f63cf1-4ba3-4969-8d3e-67d7a11c5f97
UUID:
uuid:c0f63cf1-4ba3-4969-8d3e-67d7a11c5f97
Local pid:
pubs:667681

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