Could an endo-lysosomal ion channel be the Achilles heel of SARS-CoV2?

Journal article

Recently, an interesting review appeared in Pharmacological Research presented a list of candidate drugs against SARS-CoV-2 and COVID-19 [1]. In the present insight, we highlight novel experimental evidence that the flavanone Naringenin, targeting the endo-lysosomal Two-Pore Channels (TPCs), could be added to the list of potential weapons against SARS-CoV-2 infection and COVID-19 disease

Authors: Grimm, C; Tang, R

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Elsevier
• Journal: Cell Calcium
• Volume: 88
• Pages: 102212-102212
• Publication date: 2020-05-06
• DOI: 10.1016/j.ceca.2020.102212
• EISSN: 1532-1991
• ISSN: 0143-4160
• Language: English
• Keywords: Anatomy; Internal medicine; Outbreak; 2019-20 coronavirus outbreak; Disease; Chemistry; Coronavirus disease 2019 (COVID-19); Infectious disease (medical specialty); Medicine; Pandemic; Virology; Ion channel; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Heel