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An ROR1 bi-specific T-cell engager provides effective targeting and cytotoxicity against a range of solid tumors

Abstract:

We have developed a humanized bi-specific T-cell engager (BiTE) targeting receptor tyrosine kinase-like orphan receptor 1 (ROR1), a cell surface antigen present on a range of malignancies and cancer-initiating cells. Focusing initially on pancreatic cancer, we demonstrated that our ROR1 BiTE results in T cell mediated and antigen-specific cytotoxicity against ROR1-expressing pancreatic cancer cell lines in vitro at exceedingly low concentrations (0.1 ng/mL) and low effector to target ratios. ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1080/2162402x.2017.1326437

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Institution:
University of Oxford
Division:
MSD
Department:
NDM; Jenner Institute
Role:
Author
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Funding agency for:
Gohil, SH
Publisher:
Taylor & Francis Publisher's website
Journal:
OncoImmunology Journal website
Volume:
6
Issue:
7
Pages:
1-11
Chapter number:
e1326437
Publication date:
2017-07-17
Acceptance date:
2017-04-29
DOI:
EISSN:
2162-402X
ISSN:
2162-4011
Pubs id:
pubs:816625
URN:
uri:c0cb9942-b0be-4b0a-99b9-909c9afac36a
UUID:
uuid:c0cb9942-b0be-4b0a-99b9-909c9afac36a
Local pid:
pubs:816625
Paper number:
7
Language:
English
Keywords:

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