Decreased hepcidin levels are associated with low steady-state hemoglobin in children with sickle cell disease in Tanzania

Journal article

Background The contribution of hepcidin as a regulator of iron metabolism & erythropoiesis on the severity of anemia in sickle cell disease (SCD) remains poorly characterized, especially in Sub-Saharan African populations. The aims of the study were to determine if hepcidin is associated with severity of steady-state anemia in SCD and to investigate factors associated with hepcidin and anemia in SCD. Methods Archived samples from 199 Tanzanian children, ... Expand abstract

Authors: Lee, N; Makani, J; Tluway, F; Makubi, A; Armitage, AE

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Elsevier
• Journal: EBioMedicine
• Volume: 34
• Pages: 158-164
• Publication date: 2018-07-25
• Acceptance date: 2018-07-17
• DOI: 10.1016/j.ebiom.2018.07.024
• ISSN: 2352-3964
• Pmid: 30056060
• Language: English
• Keywords: sickle cell disease; sickle cell anemia; hepcidin; iron metabolism; sub-Saharan Africa; nutrition