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Trophoblast glycoprotein (TPGB/5T4) in human placenta: expression, regulation, and presence in extracellular microvesicles and exosomes

Abstract:
Background: Many parallels exist between growth and development of the placenta and that of cancer. One parallel is shared expression of antigens that may have functional importance and may be recognized by the immune system. Here, we characterize expression and regulation of one such antigen, Trophoblast glycoprotein (TPGB; also called 5T4), in the placenta across gestation, in placentas of preeclamptic (PE) pregnancies, and in purified microvesicles and exosomes. M... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1177/1933719117707053

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Obstetrics & Gynaecology
Role:
Author
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Grant:
Programme Grant MR/ J003360/1
Michigan State University More from this funder
AgBioResearch More from this funder
Publisher:
SAGE Publisher's website
Journal:
Reproductive Sciences Journal website
Volume:
25
Issue:
2
Pages:
185-197
Publication date:
2017-05-08
Acceptance date:
2017-05-08
DOI:
EISSN:
1933-7205
ISSN:
1933-7191
Pubs id:
pubs:695651
URN:
uri:c0b49835-7f7a-4c97-9b0c-38eeca0c361e
UUID:
uuid:c0b49835-7f7a-4c97-9b0c-38eeca0c361e
Local pid:
pubs:695651
Language:
English
Keywords:

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