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Systemic and vascular oxidation limits the efficacy of oral tetrahydrobiopterin treatment in patients with coronary artery disease.

Abstract:

BACKGROUND: The endothelial nitric oxide synthase cofactor tetrahydrobiopterin (BH4) plays a pivotal role in maintaining endothelial function in experimental vascular disease models and in humans. Augmentation of endogenous BH4 levels by oral BH4 treatment has been proposed as a potential therapeutic strategy in vascular disease states. We sought to determine the mechanisms relating exogenous BH4 to human vascular function and to determine oral BH4 pharmacokinetics in both plasma and vascular...

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Publication status:
Published

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Journal:
Circulation
Volume:
125
Issue:
11
Pages:
1356-1366
Publication date:
2012-03-01
DOI:
EISSN:
1524-4539
ISSN:
0009-7322
Source identifiers:
254268
Language:
English
Keywords:
Pubs id:
pubs:254268
UUID:
uuid:c0adf47c-4184-461c-90df-6bb6105080cd
Local pid:
pubs:254268
Deposit date:
2012-12-19

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