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Does the application of X-ray contrast agents impair the clinical effect of intravenous recombinant tissue-type plasminogen activator in acute ischemic stroke patients?

Abstract:

BACKGROUND AND PURPOSE: Experimental data suggest a negative interaction between x-ray contrast agents and fibrinolytic efficacy of recombinant tissue-type plasminogen activator (rtPA). We hypothesized that the application of a contrast agent before intravenous thrombolysis with rtPA reduces its clinical efficacy in acute ischemic stroke. METHODS: We retrospectively studied consecutive ischemic stroke patients receiving contrast agents for computed tomography angiography before intravenous t...

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Publication status:
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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Stroke and Geratology
Role:
Author
Journal:
Stroke; a journal of cerebral circulation
Volume:
43
Issue:
6
Pages:
1567-1571
Publication date:
2012-06-01
DOI:
EISSN:
1524-4628
ISSN:
0039-2499
Source identifiers:
322719
Language:
English
Keywords:
Pubs id:
pubs:322719
UUID:
uuid:c0acf04c-108b-4169-b412-883536c2a554
Local pid:
pubs:322719
Deposit date:
2012-12-19

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