BACKGROUND AND PURPOSE: Experimental data suggest a negative interaction between x-ray contrast agents and fibrinolytic efficacy of recombinant tissue-type plasminogen activator (rtPA). We hypothesized that the application of a contrast agent before intravenous thrombolysis with rtPA reduces its clinical efficacy in acute ischemic stroke. METHODS: We retrospectively studied consecutive ischemic stroke patients receiving contrast agents for computed tomography angiography before intravenous t...Expand abstract
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Does the application of X-ray contrast agents impair the clinical effect of intravenous recombinant tissue-type plasminogen activator in acute ischemic stroke patients?
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