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Journal article

NF-kappaB regulates androgen receptor expression and prostate cancer growth.

Abstract:

Prostate cancers that progress during androgen-deprivation therapy often overexpress the androgen receptor (AR) and depend on AR signaling for growth. In most cases, increased AR expression occurs without gene amplification and may be due to altered transcriptional regulation. The transcription factor nuclear factor (NF)-kappaB, which is implicated in tumorigenesis, functions as an important downstream substrate of mitogen-activated protein kinase, phosphatidylinositol 3-kinase, AKT, and prot...

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Publisher copy:
10.2353/ajpath.2009.080727

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Journal:
The American journal of pathology
Volume:
175
Issue:
2
Pages:
489-499
Publication date:
2009-08-05
DOI:
EISSN:
1525-2191
ISSN:
0002-9440
URN:
uuid:c09f3167-da18-425c-85c1-8b425bfc8f53
Source identifiers:
367533
Local pid:
pubs:367533

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