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Terminal regions confer plasticity to the tetrameric assembly of human HspB2 and HspB3

Abstract:

Heterogeneity in small heat shock proteins (sHsps) spans multiple spatiotemporal regimes – from fast fluctuations of part of the protein, to conformational variability of tertiary structure, plasticity of the interfaces, and polydispersity of the inter-converting, and co-assembling oligomers. This heterogeneity and dynamic nature of sHsps has significantly hindered their structural characterisation. Atomic-coordinates are particularly lacking for vertebrate sHsps, where most available structu...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1016/j.jmb.2018.06.047

Authors


Egberts, WV More by this author
Kondrat, FDL More by this author
Hilton, GR More by this author
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Publisher:
Academic Press Publisher's website
Journal:
Journal of Molecular Biology Journal website
Volume:
430
Issue:
18B
Pages:
3297-3310
Publication date:
2018-06-30
Acceptance date:
2018-06-26
DOI:
EISSN:
0022-2836
Pubs id:
pubs:865171
URN:
uri:c059356f-b3bc-4ca0-958f-73ad42214819
UUID:
uuid:c059356f-b3bc-4ca0-958f-73ad42214819
Local pid:
pubs:865171

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