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Journal article

Transmission blocking potency and immunogenicity of a plant-produced Pvs25-based subunit vaccine against Plasmodium vivax

Abstract:

Malaria transmission blocking (TB) vaccines (TBVs) directed against proteins expressed on the sexual stages of Plasmodium parasites are a potentially effective means to reduce transmission. Antibodies induced by TBVs block parasite development in the mosquito, and thus inhibit transmission to further human hosts. The ookinete surface protein P25 is a primary target for TBV development. Recently, transient expression in plants using hybrid viral vectors has demonstrated potential as a strategy...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.vaccine.2016.05.007

Authors


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Funding agency for:
Blagborough, AM
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Funding agency for:
Blagborough, AM
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Funding agency for:
Blagborough, AM
Bill and Melinda Gates Foundation More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Vaccine Journal website
Volume:
34
Issue:
28
Pages:
3252-3259
Publication date:
2016-06-14
DOI:
EISSN:
1873-2518
ISSN:
0264-410X
URN:
uuid:c0585c7d-6644-4700-9e76-d727c6781bb9
Source identifiers:
623217
Local pid:
pubs:623217

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