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Journal article

Yeast Sen1 helicase protects the genome from transcription-associated instability.

Abstract:

Sen1 of S. cerevisiae is a known component of the NRD complex implicated in transcription termination of nonpolyadenylated as well as some polyadenylated RNA polymerase II transcripts. We now show that Sen1 helicase possesses a wider function by restricting the occurrence of RNA:DNA hybrids that may naturally form during transcription, when nascent RNA hybridizes to DNA prior to its packaging into RNA protein complexes. These hybrids displace the nontranscribed strand and create R loop struct...

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Publication status:
Published

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Authors


Mischo, HE More by this author
Gómez-González, B More by this author
Grzechnik, P More by this author
Rondón, AG More by this author
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Journal:
Molecular cell
Volume:
41
Issue:
1
Pages:
21-32
Publication date:
2011-01-05
DOI:
EISSN:
1097-4164
ISSN:
1097-2765
URN:
uuid:c053dc0a-f3cb-44c8-9d21-90e0403609d4
Source identifiers:
112492
Local pid:
pubs:112492

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