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Journal article

High-resolution structures of bacterially expressed soluble human CD59.

Abstract:

CD59 is a membrane-bound glycoprotein that protects host cells from lysis by inhibiting the terminal pathway of complement, preventing the formation and insertion of the membrane attack complex (MAC). Crystals of bacterially expressed and nonglycosylated recombinant soluble human CD59 have been obtained from three crystallization conditions, each of which gave rise to a distinct crystal form. Each crystal form led to a crystal structure at high resolution (1.15, 1.35 and 1.8 A). In one of the...

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Publication status:
Published

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Publisher copy:
10.1107/S1744309107033477

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Hughes, TR More by this author
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Journal:
Acta crystallographica. Section F, Structural biology and crystallization communications
Volume:
63
Issue:
Pt 8
Pages:
648-652
Publication date:
2007-08-05
DOI:
EISSN:
1744-3091
ISSN:
1744-3091
URN:
uuid:c039c69b-22a6-4ca9-b7b6-238f4a6e1e11
Source identifiers:
28701
Local pid:
pubs:28701

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