A family of insertion mutations between codons 67 and 70 of human immunodeficiency virus type 1 reverse transcriptase confer multinucleoside analog resistance.

Larder, BA; Bloor, S; Kemp, SD; Hertogs, K; Desmet, RL; Miller, V; Sturmer, M; Staszewski, S; Ren, J; Stammers, DK; Stuart, DI; Pauwels, R

Abstract:

To investigate the occurrence of multinucleoside analog resistance during therapy failure, we surveyed the drug susceptibilities and genotypes of nearly 900 human immunodeficiency virus type 1 (HIV-1) samples. For 302 of these, the 50% inhibitory concentrations of at least four of the approved nucleoside analogs had fourfold-or-greater increases. Genotypic analysis of the reverse transcriptase (RT)-coding regions from these samples revealed complex mutational patterns, including the previousl...

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APA Style

Larder, B. A., Bloor, S., Kemp, S. D., Hertogs, K., Desmet, R. L., Miller, V., Sturmer, M., Staszewski, S., Ren, J., Stammers, D. K., Stuart, D. I., & Pauwels, R. (1999). A family of insertion mutations between codons 67 and 70 of human immunodeficiency virus type 1 reverse transcriptase confer multinucleoside analog resistance. Antimicrobial Agents and Chemotherapy, 43(8), 1961–1967.

MLA Style

Larder, B. A., et al. “A Family of Insertion Mutations between Codons 67 and 70 of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Confer Multinucleoside Analog Resistance.” Antimicrobial Agents and Chemotherapy, vol. 43, no. 8, Antimicrobial agents and chemotherapy, 1999, pp. 1961–67.

Chicago Style

Larder, BA, S Bloor, SD Kemp, K Hertogs, RL Desmet, V Miller, M Sturmer, et al. 1999. “A Family of Insertion Mutations between Codons 67 and 70 of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Confer Multinucleoside Analog Resistance.” Antimicrobial Agents and Chemotherapy 43 (8): 1961–67.
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