Journal article
A family of insertion mutations between codons 67 and 70 of human immunodeficiency virus type 1 reverse transcriptase confer multinucleoside analog resistance.
- Abstract:
-
To investigate the occurrence of multinucleoside analog resistance during therapy failure, we surveyed the drug susceptibilities and genotypes of nearly 900 human immunodeficiency virus type 1 (HIV-1) samples. For 302 of these, the 50% inhibitory concentrations of at least four of the approved nucleoside analogs had fourfold-or-greater increases. Genotypic analysis of the reverse transcriptase (RT)-coding regions from these samples revealed complex mutational patterns, including the previousl...
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- Publication status:
- Published
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Bibliographic Details
- Journal:
- Antimicrobial agents and chemotherapy
- Volume:
- 43
- Issue:
- 8
- Pages:
- 1961-1967
- Publication date:
- 1999-08-01
- EISSN:
-
1098-6596
- ISSN:
-
0066-4804
- Source identifiers:
-
30
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:30
- UUID:
-
uuid:c02b6582-c197-4b96-8d40-3b9caf461d22
- Local pid:
- pubs:30
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 1999
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