Journal article icon

Journal article

A family of insertion mutations between codons 67 and 70 of human immunodeficiency virus type 1 reverse transcriptase confer multinucleoside analog resistance.

Abstract:

To investigate the occurrence of multinucleoside analog resistance during therapy failure, we surveyed the drug susceptibilities and genotypes of nearly 900 human immunodeficiency virus type 1 (HIV-1) samples. For 302 of these, the 50% inhibitory concentrations of at least four of the approved nucleoside analogs had fourfold-or-greater increases. Genotypic analysis of the reverse transcriptase (RT)-coding regions from these samples revealed complex mutational patterns, including the previousl...

Expand abstract
Publication status:
Published

Actions


Authors


Expand authors...
Journal:
Antimicrobial agents and chemotherapy
Volume:
43
Issue:
8
Pages:
1961-1967
Publication date:
1999-08-05
EISSN:
1098-6596
ISSN:
0066-4804
URN:
uuid:c02b6582-c197-4b96-8d40-3b9caf461d22
Source identifiers:
30
Local pid:
pubs:30

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP