Journal article
On the atomic structure of cocaine in solution
- Abstract:
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Cocaine is an amphiphilic drug which has the ability to cross the blood–brain barrier (BBB). Here, a combination of neutron diffraction and computation has been used to investigate the atomic scale structure of cocaine in aqueous solutions. Both the observed conformation and hydration of cocaine appear to contribute to its ability to cross hydrophobic layers afforded by the BBB, as the average conformation yields a structure which might allow cocaine to shield its hydrophilic regions from a l...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Accepted manuscript, pdf, 6.3MB, Terms of use)
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- Publisher copy:
- 10.1039/C5CP06090G
Authors
Funding
Bibliographic Details
- Publisher:
- Royal Society of Chemistry
- Journal:
- Physical Chemistry Chemical Physics More from this journal
- Volume:
- 18
- Issue:
- 2016
- Pages:
- 991-999
- Publication date:
- 2015-11-27
- Acceptance date:
- 2015-11-27
- DOI:
- EISSN:
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1463-9084
- ISSN:
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1463-9076
Item Description
- Pubs id:
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pubs:579710
- UUID:
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uuid:bff6e119-ace6-4e20-a33e-58d44a3b90ed
- Local pid:
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pubs:579710
- Source identifiers:
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579710
- Deposit date:
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2015-12-14
Terms of use
- Copyright holder:
- Owner Societies
- Copyright date:
- 2015
- Notes:
- © the Owner Societies 2016. This is the accepted manuscript version of the paper. The final version is available from the Royal Society of Chemistry at: https://doi.org/10.1039/C5CP06090G
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