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Modulation by flavonoids of cell multidrug resistance mediated by P-glycoprotein and related ABC transporters.

Abstract:

Cancer cell resistance to chemotherapy is often mediated by overexpression of P-glycoprotein, a plasma membrane ABC (ATP-binding cassette) transporter which extrudes cytotoxic drugs at the expense of ATP hydrolysis. P-glycoprotein (ABCB1, according to the human gene nomenclature committee) consists of two homologous halves each containing a transmembrane domain (TMD) involved in drug binding and efflux, and a cytosolic nucleotide-binding domain (NBD) involved in ATP binding and hydrolysis, wi...

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Publisher copy:
10.1007/s00018-002-8424-8

Authors


Di Pietro, A More by this author
Conseil, G More by this author
Pérez-Victoria, JM More by this author
Baubichon-Cortay, H More by this author
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Journal:
Cellular and molecular life sciences : CMLS
Volume:
59
Issue:
2
Pages:
307-322
Publication date:
2002-02-05
DOI:
EISSN:
1420-9071
ISSN:
1420-682X
URN:
uuid:bfb64f10-df8c-4ed4-b6ba-d451e54ed0de
Source identifiers:
237546
Local pid:
pubs:237546

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