Soluble receptor for advanced glycation end products as an indicator of pulmonary vascular injury after cardiac surgery

Journal article

Background: Cardiac surgery is frequently complicated by an acute vascular lung injury and this may be mediated, at least in part, by the (soluble) receptor for advanced glycation end products (sRAGE).Methods: In two university hospital intensive care units, circulating sRAGE was measured together with the 68Gallium-transferrin pulmonary leak index (PLI), a measure of pulmonary vascular permeabiliy, in 60 consecutive cardiac surgery patients stratified by the amount of blood transfusion, within 3 hours of admission to the intensive care.Results: Cardiac surgery resulted in elevated plasma sRAGE levels compared to baseline (315 ± 181 vs 110 ± 55 pg/ml, P = 0.001). In 37 patients the PLI was elevated 50% above normal. The PLI correlated with sRAGE (r2 = 0.11, P = 0.018). Plasma sRAGE discriminated well between those with an elevated PLI and those with a normal PLI (area under the operator curve 0.75; P = 0.035; 95% CI 0.55-0.95), with 91% sensitivity but low specificity of 36% at a cutoff value of 200 pg/mL

Authors: Tuinman, PR; Cornet, AD; Kuipers, MT; Vlaar, AP; Schultz, MJ

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: BioMed Central
• Journal: BMC Pulmonary Medicine
• Volume: 13
• Issue: 1
• Pages: 76-76
• Publication date: 2013-12-16
• DOI: 10.1186/1471-2466-13-76
• EISSN: 1471-2466
• ISSN: 1471-2466
• Language: English
• Keywords: Medicine; Internal medicine; Cardiology; Intensive care; Glycation; Cardiac surgery; Receptor; Surgery; Gastroenterology; Intensive care medicine