Journal article
Genetically proxied glucose-lowering drug target perturbation and risk of cancer: a Mendelian randomisation analysis
- Abstract:
-
Aims/hypothesis: Epidemiological studies have generated conflicting findings on the relationship between glucose-lowering medication use and cancer risk. Naturally occurring variation in genes encoding glucose-lowering drug targets can be used to investigate the effect of their pharmacological perturbation on cancer risk.
Expand abstract
Methods: We developed genetic instruments for three glucose-lowering drug targets (peroxisome proliferator activated receptor γ [...
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Version of record, pdf, 3.0MB, Terms of use)
-
(Preview, Supplementary materials, pdf, 225.7KB, Terms of use)
-
- Publisher copy:
- 10.1007/s00125-023-05925-4
Authors
Contributors
+ Neal, D
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Surgical Sciences
- Role:
- Contributor
+ Cancer Research UK
More from this funder
- Funder identifier:
- https://ror.org/054225q67
- Grant:
- 29017
- 29019
+ Medical Research Council
More from this funder
- Funder identifier:
- https://ror.org/03x94j517
- Grant:
- MR/M012190/1
- Publisher:
- Springer
- Journal:
- Diabetologia More from this journal
- Volume:
- 66
- Issue:
- 8
- Pages:
- 1481-1500
- Place of publication:
- Germany
- Publication date:
- 2023-05-12
- Acceptance date:
- 2023-03-13
- DOI:
- EISSN:
-
1432-0428
- ISSN:
-
0012-186X
- Pmid:
-
37171501
- Language:
-
English
- Keywords:
- Pubs id:
-
1511272
- Local pid:
-
pubs:1511272
- Deposit date:
-
2025-01-22
Terms of use
- Copyright holder:
- Yarmolinsky et al
- Copyright date:
- 2023
- Rights statement:
- © The Author(s) 2023. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
If you are the owner of this record, you can report an update to it here: Report update to this record