Journal article
Differential gene expression in macrophages from human atherosclerotic plaques shows convergence on pathways implicated by genome-wide association study risk variants
- Abstract:
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Objective
Plaque macrophages are intricately involved in atherogenesis and plaque destabilization. We sought to identify functional pathways in human plaque macrophages that are differentially regulated in respect of (1) plaque stability and (2) lipid content. We hypothesized that differentially regulated macrophage gene sets would relate to genome-wide association study variants associated with risk of acute complications of atherosclerosis.
Approach and Results
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
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- Files:
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(Preview, Version of record, pdf, 3.0MB, Terms of use)
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- Publisher copy:
- 10.1161/ATVBAHA.118.311209
Authors
Funding
+ British Heart Foundation
More from this funder
Funding agency for:
Biasiolli, L
Grant:
PG/15/74/31747
RE/13/1/30181
+ Wellcome Trust
More from this funder
Funding agency for:
Goel, A
Kyriakou, T
Choudhury, R
Grant:
Senior Clinical Fellow
090532/Z/09/Z
+ Novo Nordisk Foundation
More from this funder
Funding agency for:
Goel, A
Watkins, H
Choudhury, R
Grant:
Senior Clinical Fellow
Bibliographic Details
- Publisher:
- American Heart Association
- Journal:
- Arteriosclerosis, Thrombosis, and Vascular Biology More from this journal
- Volume:
- 38
- Issue:
- 1
- Pages:
- 2718–2730
- Publication date:
- 2018-09-06
- Acceptance date:
- 2018-08-28
- DOI:
- EISSN:
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1524-4636
- ISSN:
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1079-5642
Item Description
- Keywords:
- Pubs id:
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pubs:918782
- UUID:
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uuid:bf8212c0-0fcb-42f7-97da-502056a54541
- Local pid:
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pubs:918782
- Source identifiers:
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918782
- Deposit date:
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2018-10-14
Terms of use
- Copyright holder:
- Chai et al
- Copyright date:
- 2018
- Notes:
- © 2018 The Authors. Arteriosclerosis, Thrombosis, and Vascular Biology is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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