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The recombinant origin of emerging human norovirus GII.4/2008: intra-genotypic exchange of the capsid P2 domain.

Abstract:

GII.4 noroviruses are a major cause of acute gastroenteritis in humans. A new variant of GII.4, the 2008 variant, has recently increased its prevalence on a global scale. A previous study of this variant in Japan suggested that it might be of recombinant origin, with a breakpoint at the ORF1-ORF2 junction. Here, examination of the evolutionary origin of the 2008 variant based on a larger sample of worldwide GII.4 norovirus sequences revealed a more complex pattern of recombination between the...

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Publication status:
Published

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Publisher copy:
10.1099/vir.0.039057-0

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Journal:
The Journal of general virology
Volume:
93
Issue:
Pt 4
Pages:
817-822
Publication date:
2012-04-05
DOI:
EISSN:
1465-2099
ISSN:
0022-1317
URN:
uuid:bf7c4388-3222-445e-8786-569be12f709c
Source identifiers:
237800
Local pid:
pubs:237800

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