Journal article
Mortality risk of COVID-19 in elderly males with comorbidities: a multi-country study
- Abstract:
- The COVID-19 pandemic causes severe morbidity and mortality. This multi-country study aimed to explore risk factors that drive mortality in COVID-19 patients who received neither dexamethasone nor remdesivir. We analyzed a cohort of 568 survivors and 507 non-survivors from China, European regions, and North America. Elderly males ≥70 years accounted for only 25% of survivors, but this rate was significantly higher in non-survivors from China (55%), European regions (63%), and North America (47%). Compared with survivors, non-survivors had more incidences of comorbidities such as cerebrovascular disease and chronic obstructive pulmonary disease (COPD, p-values<0.05). Survival analyses revealed age, male gender, shortness of breath, cerebrovascular disease, and COPD as mortality-associated factors. Survival time from symptom onset was significantly shorter in elderly versus young patients (median: 29 versus 62 days), males versus females (median: 46 versus 59 days), and patients with versus without comorbidities (mean: 41 versus 61 days). Mortality risk was higher in elderly males with comorbidities than in young females without comorbidities (p-value<0.01). Elderly male survivors with comorbidities also had longer hospital stays than other survivors (25 versus 18.5 days, p-value<0.01). Overall, the high mortality risk in elderly males with COVID-19-associated comorbidities supports early prevention and critical care for elderly populations.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, 3.2MB, Terms of use)
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- Publisher copy:
- 10.18632/aging.202456
Authors
- Publisher:
- Impact Journals
- Journal:
- Aging More from this journal
- Volume:
- 13
- Issue:
- 1
- Pages:
- 27-60
- Publication date:
- 2020-12-31
- Acceptance date:
- 2020-12-09
- DOI:
- EISSN:
-
1945-4589
- Pmid:
-
33472167
- Language:
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English
- Keywords:
- Pubs id:
-
1157970
- Local pid:
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pubs:1157970
- Deposit date:
-
2021-02-19
Terms of use
- Copyright holder:
- G Li et al.
- Copyright date:
- 2020
- Rights statement:
- © 2020 Li et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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