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Identification of arylamine N-acetyltransferase inhibitors as an approach towards novel anti-tuberculars.

Abstract:

New anti-tubercular drugs and drug targets are urgently needed to reduce the time for treatment and also to identify agents that will be effective against Mycobacterium tuberculosis persisting intracellularly. Mycobacteria have a unique cell wall. Deletion of the gene for arylamine N-acetyltransferase (NAT) decreases mycobacterial cell wall lipids, particularly the distinctive mycolates, and also increases antibiotic susceptibility and killing within macrophage of Mycobacterium bovis BCG. The...

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Publication status:
Published

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Publisher copy:
10.1007/s13238-010-0006-1

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Publisher:
Higher Education Press
Journal:
Protein and cell
Volume:
1
Issue:
1
Pages:
82-95
Publication date:
2010-01-05
DOI:
EISSN:
1674-8018
ISSN:
1674-800X
URN:
uuid:bf5a0844-ed6f-4cb4-962a-c3e847e54980
Source identifiers:
110208
Local pid:
pubs:110208

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