Identification of arylamine N-acetyltransferase inhibitors as an approach towards novel anti-tuberculars.

Journal article

New anti-tubercular drugs and drug targets are urgently needed to reduce the time for treatment and also to identify agents that will be effective against Mycobacterium tuberculosis persisting intracellularly. Mycobacteria have a unique cell wall. Deletion of the gene for arylamine N-acetyltransferase (NAT) decreases mycobacterial cell wall lipids, particularly the distinctive mycolates, and also increases antibiotic susceptibility and killing within macrophage of Mycobacterium bovis BCG. The...

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Authors: Westwood, I; Bhakta, S; Russell, A; Fullam, E; Anderton, M

• Publication status: Published
• Publisher: Higher Education Press
• Journal: Protein and cell
• Volume: 1
• Issue: 1
• Pages: 82-95
• Publication date: 2010-01-01
• DOI: 10.1007/s13238-010-0006-1
• EISSN: 1674-8018
• ISSN: 1674-800X
• Language: English
• Keywords: Enzyme Inhibitors; High-Throughput Screening Assays; Arylamine N-Acetyltransferase; Protein Conformation; Mycobacterium bovis; Triazoles; Antitubercular Agents; Structure-Activity Relationship; Mycobacterium tuberculosis; Humans