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Two-pore channels for integrative Ca signaling.

Abstract:

Two-pore channels (TPCs) are related to voltage-gated Ca(2+) and Na(+) channels. They most likely work as dimers with each of the two TPC protein subunits containing two pore-forming domains. Recent studies suggest that TPCs are expressed on the membranes of endosomes and lysosomes where they form receptors for nicotinic acid adenine dinucleotide phosphate (NAADP), the most potent Ca(2+) mobilizing messenger inside cells. Upon activation by NAADP, Ca(2+) release from endolysosomal stores thro...

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Publisher copy:
10.4161/cib.3.1.9793

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology, BHF Centre of Research Excellence
Role:
Author
Journal:
Communicative and integrative biology
Volume:
3
Issue:
1
Pages:
12-17
Publication date:
2010-01-05
DOI:
EISSN:
1942-0889
ISSN:
1942-0889
URN:
uuid:bf2444e6-a60e-4cb3-9fb8-6478a90ee5bb
Source identifiers:
106149
Local pid:
pubs:106149

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