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Modelling the dynamics of LCMV infection in mice: II. Compartmental structure and immunopathology.

Abstract:

In this study, we develop a mathematical model for analysis of the compartmental aspects and immunopathology of lymphocytic choriomeningitis virus (LCMV) infection in mice. We used sets of original and published data on systemic (extrasplenic) virus distribution to estimate the parameters of virus growth and elimination for spleen and other anatomical compartments, such as the liver, kidney, thymus and lung as well as transfer rates between blood and the above organs. A mathematical model qua...

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Publication status:
Published

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Publisher copy:
10.1006/jtbi.2003.3180

Authors


Bocharov, G More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division, Biomedical Research Centre
Journal:
Journal of theoretical biology
Volume:
221
Issue:
3
Pages:
349-378
Publication date:
2003-04-05
DOI:
EISSN:
1095-8541
ISSN:
0022-5193
URN:
uuid:bf1d1511-d6d3-4435-bacd-c17ee1e7b728
Source identifiers:
12276
Local pid:
pubs:12276

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