Journal article icon

Journal article

Mechanical design principles of a mitotic spindle

Abstract:

An organised spindle is crucial to the fidelity of chromosome segregation, but the relationship between spindle structure and function is not well understood in any cell type. The anaphase B spindle in fission yeast has a slender morphology and must elongate against compressive forces. This ‘pushing’ mode of chromosome transport renders the spindle susceptible to breakage, as observed in cells with a variety of defects. Here we perform electron tomographic analyses of the spindle, which sugge...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.7554/eLife.03398

Authors


More by this author
Department:
Sir William Dunn School of Pathology
Role:
Author
Journal:
eLife
Volume:
December 2014
Publication date:
2014-12-18
Acceptance date:
2014-12-17
DOI:
EISSN:
2050-084X
ISSN:
2050-084X
Source identifiers:
e03398
Language:
English
Keywords:
Subjects:

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP