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Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1.

Abstract:

Many growth factors whose receptors are protein tyrosine kinases stimulate the MAP kinase pathway by activating first the GTP-binding protein Ras and then the protein kinase p74raf-1. p74raf-1 phosphorylates and activates MAP kinase kinase (MAPKK). To understand the mechanism of activation of MAPKK, we have identified Ser217 and Ser221 of MAPKK1 as the sites phosphorylated by p74raf-1. This represents the first characterization of sites phosphorylated by this proto-oncogene product. Ser217 an...

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Publication status:
Published

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Authors


Alessi, DR More by this author
Campbell, DG More by this author
Sithanandam, G More by this author
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Journal:
The EMBO journal
Volume:
13
Issue:
7
Pages:
1610-1619
Publication date:
1994-04-05
EISSN:
1460-2075
ISSN:
0261-4189
URN:
uuid:bef492d5-b812-415e-902a-8adced3e7725
Source identifiers:
223799
Local pid:
pubs:223799

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