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Journal article

Coupled enhancer and coding sequence evolution of a homeobox gene shaped leaf diversity

Abstract:

Here we investigate mechanisms underlying the diversification of biological forms using crucifer leaf shape as an example. We show that evolution of an enhancer element in the homeobox gene REDUCED COMPLEXITY (RCO) altered leaf shape by changing gene expression from the distal leaf blade to its base. A single amino acid substitution evolved together with this regulatory change, which reduced RCO protein stability, preventing pleiotropic effects caused by its altered gene expression. We detect...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1101/gad.290684.116

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Department:
St Hildas College
Role:
Author
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Funding agency for:
Mentink, RA
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Funding agency for:
Tsiantis, M
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Funding agency for:
Tsiantis, M
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Publisher:
Cold Spring Harbor Laboratory Press Publisher's website
Journal:
Genes Development Journal website
Volume:
30
Pages:
2370-2375
Publication date:
2016-11-16
Acceptance date:
2016-10-25
DOI:
EISSN:
1549-5477
ISSN:
0890-9369
Pubs id:
pubs:660328
URN:
uri:bee1c6b2-559b-41cc-ad3a-fbd4d62d0f59
UUID:
uuid:bee1c6b2-559b-41cc-ad3a-fbd4d62d0f59
Local pid:
pubs:660328

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